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| HCV treatment program reduced disease burden in prison |
| By healio.com- Moorjani H. Emerg |
| Published: 01/16/2015 |
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A treatment program comprising triple therapy with telaprevir, interferon and ribavirin was successful in managing hepatitis C in correctional facilities, which are known to be sites of concentrated infection, according to recent data. Researchers from the New York Department of Corrections and Community Supervision (NYDOCCS) piloted an HCV treatment program for a group of 50 patients with genotype 1a or1b HCV. Participants were aged 21 to 67 years, HIV-negative, exhibited no uncontrolled mental health issues and had liver fibrosis assessed at METAVIR stage 2 or 3, or stage 4 with compensation. Seventy-six percent were treatment-naive, 14% had relapsed, 8% had achieved partial response to previous treatment, and 2% had failed to respond to any previous treatment. The novel agents evaluated included telaprevir (Incivek, Vertex), pegylated interferon, and ribavirin. Participants underwent assessment by an infectious disease consultant, received mandatory patient education, and attended primary and specialty follow-up appointments and screening. They were administered antihistamine prophylaxis prior to treatment initiation, and high potency topical steroid creams were also provided to all patients at the start of treatment with instructions to apply twice daily at the sign of a rash. During each weekly interferon injection session, nurses asked patients about rash or itching symptoms. Follow-up visits with the infectious disease consultant were conducted remotely using video and audio equipment. Read More. |
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